甲状腺癌进口靶向药——凡德他尼(Vandetanib)不良反应

印度代购提示您，本品不良反应：

≤300mg/d时耐受性良好。最常见的毒副作用是腹泻、皮疹、恶心、 高血压、厌食、无症状的QT间期延长和蛋白尿;随着剂量增加。可能出现低磷酸盐血症、毛囊炎、转氨酶升高、非特异性肠梗阻、血小板减小、充血性心衰、深静脉血栓、肺栓塞等。最常见的剂量限制性毒性(DLTs)是腹泻、高血压和皮疹。

The tolerance was good when ≤300mg/d. The most common side effects were diarrhea, rash, nausea, hypertension, anorexia, asymptomatic QT prolongation, and proteinuria. As the dose increases. Hypophosphatemia, folliculitis, elevated aminotransferase, nonspecific intestinal obstruction, thrombocytopenia, congestive heart failure, deep vein thrombosis, pulmonary embolism, etc. The most common dose-limiting toxicities (DLTs) are diarrhea, hypertension, and rash.

Vandetanib常见(10%以上)的不良反应包括感冒、支气管炎、上呼吸道感染、尿路感染、食欲下降、失眠抑郁、头晕目眩、视力模糊、长QT综合征、高血压、胃痛、腹泻、恶心、呕吐、消化不良、皮疹、痤疮、干燥瘙痒、尿液中有蛋白质、肾结石、虚弱、疲劳、疼痛和水肿。

Vandetanib常见(占1 %至10%的人)不良反应包括肺炎、败血症、流感、膀胱炎、鼻窦炎、喉炎、毛囊炎、肾脏感染、低甲状腺激素水平、低钾、高钙水平、低钠水平、焦虑、战栗、昏睡、意识丧失、平衡失调、味觉的变化、视觉障碍、光晕视觉、角膜病、高血压危象、鼻子出血、咳血、结肠炎、口干、口腔炎、便秘、胃炎、排尿痛、血尿、肾衰竭、尿频、发烧。

Vandetanib is common (accounting for 1 % to 10%) adverse reactions including pneumonia, sepsis, influenza, cystitis, sinusitis, laryngitis, folliculitis, kidney infections, low level of thyroid hormone sodium calcium, low potassium, high level and low level, anxiety, panic, lethargy and loss of consciousness, the change of balance disorders, taste, visual impairment, halo vision, corneal disease, hypertensive crisis, nose bleeding, coughing up blood, knot Enteritis, dry mouth, stomatitis, constipation, gastritis, painful urination, hematuria, renal failure, frequent urination, fever.