甲状腺癌进口靶向药——凡德他尼(Vandetanib)注意事项

印度代购提示您，本品注意事项：

1.开始使用vandetanib治疗后2-4周和8-12周，和其后每3个月及剂量调整后，监查心电图和血清钾，钙和TSH水平。当剂量减低适当。

1. Ekg and serum potassium, calcium, and TSH levels were monitored 2 -- 4 weeks and 8 -- 12 weeks after initiation of vandetanib treatment, and every 3 months thereafter and after dose adjustment. When dose reduction is appropriate.

2.严重皮肤反应可能促使死亡，应永远终止vandetanib。

3.存在非特异性呼吸征象和症状例如缺氧，胸腔积液，咳嗽，或呼吸困难等患者。建议及时报告呼吸症状。

4.出现严重缺血性脑血管事件，出血，心衰，腹泻，甲状腺低下症，高血压，和可逆性后脑白质脑病综合征应终止vandetanib。

5.vandetanib给予妊娠妇女可能致死。建议妇女接受vandetanib治疗后4个月避免妊娠。

6.因为QT延长，提高了尖端扭转型室性心动过速和骤死的风险，只能通过严格分配计划(vandetanib REMS)计划得到vandetanib。只有经认证的处方者和药房能够分配到vandetanib。

6. Vandetanib is available only through a strict allocation plan (Vandetanib REMS) because of QT prolongation, which increases the risk of tachycardia and sudden death at the tip. Only certified prescribers and pharmacies can dispense vandetanib.