前列腺癌进口抗癌药——比卡鲁胺服用注意事项及不良反应

印度代购提示，本品注意事项：

本品广泛在肝脏代谢。数据表明严重肝损害的病人药物清除可能会减慢，由此可能导致蓄积。所以本品对有中、重度肝损伤的病人应慎用。由于可能出现肝脏改变，应考虑定期进行肝功能检测。主要的改变一般在本品治疗的最初6个月内出现。严重的肝功能改变很少见于本品的治疗(见不良反应)。如果出现严重改变应停止本品治疗。本品显示抑制细胞色素P450(CYP3A4)活性，因此当与主要由CYP3A4代谢的药物联合应用时应谨慎(见禁忌和药物相互作用)。

This product is widely metabolized in the liver. Data suggest that drug clearance may be slowed in patients with severe liver damage, which may lead to accumulation. Therefore, this product should be used with caution for patients with moderate or severe liver injury. Regular liver function tests should be considered because of the possibility of liver changes. Major changes generally occur within the first 6 months of treatment. Severe changes in liver function are rarely seen in the treatment of this product (see adverse reactions). Discontinue treatment if serious changes occur. This product shows inhibition of cytochrome P450(CYP3A4) activity and should therefore be used with caution when combined with drugs primarily metabolized by CYP3A4 (see contraindications and drug interactions).

印度代购提示，本品不良反应：

奥拉帕尼最常见的不良反应（≥20%）的临床试验是贫血，恶心，乏力（包括乏力），呕吐，腹泻，消化不良，头痛，食欲下降，咳嗽，关节痛，肌痛，背部疼痛，皮炎/皮疹。

1、高血压：在治疗期间，定期检查你的血压，出现异常，及时治疗。

2、恶心、呕吐：吃少量的食物，按照医生的处方服用药物。

3、皮炎/皮疹：保证皮肤清洁，避免阳光暴晒。

4、背痛：如果轻微的话，不用担心。如果出现严重背痛的患者，在医生指导下服用一些缓解背痛的药物或者停药、减少剂量。

5、腹泻：建议患者以清淡饮食为主，避免食用辛辣食物和奶制品(会加重腹泻)。

6、食欲下降：饮食应清香可口、荤素搭配，可以遵循服用一些开胃健脾的药等。

6, appetite loss: the diet should be fragrant and delicious, meat and vegetable collocation, can follow some appetizers and spleen-strengthening drugs.